The Portuguese international has been on the outer for some time now due to hamstring injuries and for a lack of living up to his hefty fee which United paid Sporting Lisbon.
David Moyes is ready to revamp the squad during the next window as well which could be the ultimate factor in deciding Nani's future.
“Nani is a very important player and at this time the only thing I can say is that he is likely to leave Manchester,” Pastorello told Violanews.com.
The 27 year-old could be set for a move to Italy with Pastorello revealing that a move to Fiorentina could be on the cards.
“The problem for Fiorentina and other Italian clubs is the player’s salary," he added. "But we will evaluate all bids.
“Our relationship with United is great. Fiorentina have to speak with Manchester United about Anderson and maybe there will be an opportunity to talk about Nani, too.”